999 – Impaired Duodenal Epithelial Barrier and Secretory Functions in Non-Ulcer Dyspepsia

Duodenal ulcer and recurrent dyspepsia.

A survey of recurrent indigestion in four general practices (19,619 patients) showed a wide range of dyspeptic complaints. Of these 82 (4.2 per 1,000) already had a proved ulcer and 144 (7.3 per 1,000) had symptoms suggesting a duodenal ulcer and had either not been investigated or had previously had a normal barium meal. A duodenal ulcer was found radiologically in half the men (46 out of 95) ...

CagA and VacAgenotypes in peptic ulcer disease and non-ulcer dyspepsia: acase-control study

  Background :The cag pathogenicity island includes a number of genes, including cytotoxin-associated protein A (cagA) and vacuolatingcytotoxin (vacA) genotypes, which are associated with bacterial virulence. Although the role of cagA and vacA in the virulence of Helicobacter pylori (H. pylori) is well-established in epidemiological studies, the relationship between the cagA and vacA genotypes ...

Non-ulcer dyspepsia.

Understanding non ulcer dyspepsia.

Non ulcer dyspepsia is one of the most common problems encountered in primary care practice. The underlying pathophysiology of non ulcer dyspepsia is not fully understood, but it is known that this condition is associated with H. pylori infection and motility disorder. The presenting abdominal symptoms are non specific: they include bloating, belching, flatulence, excessive fullness after eatin...

Campylobacterpyloridis in non-ulcer dyspepsia

Antibody titres to Campylobacter pyloridis in serum and gastric juice were estimated by an enzyme linked immunosorbent assay (ELISA) to whole organisms obtained from bacterial culture in 39 patients with non-ulcer dyspepsia. Whereas 20 of the 21 patients with chronic gastritis had gastric C pyloridis, 17 patients with no Cpyloridis had normal histology in the gastric antrum and body. Significan...